PACC1 - proton activated chloride channel 1 Gene

Also Known as PAC; ASOR; hPAC; PAORAC; C1orf75; TMEM206; hTMEM206

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55248

About PACC1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,363,928-212,414,886 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Broad expression in brain (RPKM 7.4), kidney (RPKM 4.2) and 23 other tissues.

Summary

Enables pH-gated Chloride Channel activity. Involved in chloride transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PACC1 Products (5)

mRNA Protein Name
NM_001198862.2 NP_001185791.1 proton-activated chloride channel isoform 1
NM_001377478.1 NP_001364407.1 proton-activated chloride channel isoform 3
NM_001377479.1 NP_001364408.1 proton-activated chloride channel isoform 4
NM_001377480.1 NP_001364409.1 proton-activated chloride channel isoform 5
NM_018252.3 NP_060722.2 proton-activated chloride channel isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pH-gated chloride channel activity IDA
IDA: Inferred from direct assay
31023925 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in chloride transport IDA
IDA: Inferred from direct assay
31023925 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
31023925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACC1 Protein Structure

TMEM206

TMEM206: TMEM206 protein family (54 - 350)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

proton-activated chloride channel

  • acid-sensitive outwardly rectifying channel

PACC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PACC1 Q9H813 TMEM147 Homo sapiens Q9BVK8
Anti Tag CoIP
33961781
Intra
PACC1 Q9H813 TMEM147 Homo sapiens Q9BVK8
Anti Tag CoIP
28514442
Intra
PACC1 Q9H813 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09953 PACC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PACC1 VGNC VGNC:36028
Felis catus PACC1 VGNC VGNC:64018
Mus musculus PACC1 MGD MGI:1914200
Macaca mulatta PACC1 VGNC VGNC:75678
Rattus norvegicus PACC1 RGD RGD:1359339
Canis familiaris PACC1 VGNC VGNC:47525
Others PACC1 NCBI