LY3056480
LY3056480 is a γ-secretase inhibitor. LY3056480 inhibits the Notch signaling pathway, upregulates Atoh1, promotes hair cell regeneration, and drives supporting cell transdifferentiation. LY3056480 is applicable to research related to sensorineural hearing loss.
For research use only. We do not sell to patients.
- CAS No.: 2064292-78-8
- Formula: C23H28F3N3O4
- Molecular Weight:467.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
LY3056480 induces the regeneration of mammalian cochlear sensory hair cells by inhibiting the Notch signaling pathway and relieving its "lateral inhibition" on inner ear supporting cells[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 2064292-78-8
-
Molecular Weight 467.48
-
Formula C23H28F3N3O4
-
SMILES
COC1=CC2=C([C@@H](C(C=C3N2CCC3(C)C)=O)NC([C@@H](NC(CCC(F)(F)F)=O)C)=O)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Schilder AGM, et al. A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. Nature communications. 2024 Mar 01;15(1):1896. [Content Brief]
[2]. Samarajeewa A, et al. Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration. Molecular therapy : the journal of the American Society of Gene Therapy. 2019 May 08;27(5):904-911. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3056480 Related Classifications
HY-158012 Related Classifications
Powered by Bioz