WEE1
WEE1 is the archetypal G2 checkpoint kinase, conserved from the fission yeast Wee1 that sets cell size by delaying mitosis. It phosphorylates the inhibitory Tyr15 of CDK1 and CDK2, holding cyclin-CDK complexes inactive until DNA replication and repair are complete, at which point CDC25 phosphatases reverse the mark. DNA damage stabilizes WEE1 through p53 and checkpoint signaling, reinforcing arrest. WEE1 is overexpressed in many tumors, especially those with defective G1 checkpoints such as TP53-mutant cancers, rendering them reliant on the G2 gate. The inhibitor adavosertib exploits this synthetic lethality, validating WEE1 as an anticancer target. Recombinant WEE1 supports these studies.
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WEE1 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
