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Cat. No.: HY-147834

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STING agonist-9

STING agonist-9 (Compound 45) is a potent STING agonist with an EC₅₀ of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2653337-73-4
Formula: C₃₉H₄₇N₁₃O₆S
Molecular Weight:825.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

STING agonist-9 Chemical Structure

CAS No.: 2653337-73-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

STING agonist-9 (Compound 45) is a potent STING agonist with an EC₅₀ of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity^[1].

IC₅₀ & Target

EC₅₀: 1.2 nM (h-STING), 32.82 μM (m-STING)^[1]

In Vitro

STING agonist-9 (Compound 45) directly binds to various h-STING isoforms and m-STING^[1].
STING agonist-9 potently activates both ISG and NF-κB signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STING agonist-9 (Compound 45) significantly inhibits the tumor growth in allograft 4T1 and CT26 tumor models by systemic administration, and induces tumor regression in CT26 tumor model without inducing weight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2653337-73-4
Molecular Weight 825.94
Formula C₃₉H₄₇N₁₃O₆S
SMILES

O=C(C1=CC(OCCCN2CCOCC2)=C3C(N=C(NC(C4=CC(C)=NN4CC)=O)N3C/C=C/CN5C(NC(C6=CC(C)=NN6CC)=O)=NC7=C5SC(C(N)=O)=C7)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Niu J, et al. Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem. 2022 Aug 5;238:114482. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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