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Cat. No.: HY-187386

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dsNec-1

dsNec-1 is a radical-trapping antioxidant. dsNec-1 inhibits lipid peroxidation. dsNec-1 inhibits ferroptosis in mouse embryonic fibroblasts.

For research use only. We do not sell to patients.

CAS No.: 200804-78-0
Formula: C₁₃H₁₁N₃OS
Molecular Weight:257.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

dsNec-1 Chemical Structure

CAS No.: 200804-78-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

dsNec-1 is a radical-trapping antioxidant. dsNec-1 inhibits lipid peroxidation. dsNec-1 inhibits ferroptosis in mouse embryonic fibroblasts^[1].

In Vitro

dsNec-1 (200 μM; up to 6 h) potently inhibits lipid peroxidation in preoxidized egg Phosphatidylcholine (Phosphatidylcholines, egg) (HY-125854) liposomes, completely suppressing peroxidation with no induction period^[1].
dsNec-1 (8 μM; up to 6 h) acts as a radical-trapping antioxidant in native egg phosphatidylcholine liposomes, with a measured peroxyl radical-trapping rate constant of 5.5 M^-1s^-1^[1].
dsNec-1 (1 h prior to RSL3 (HY-100218A) treatment, total incubation including RSL3 of 12-16 h) potently suppresses RSL3-induced ferroptosis in Pfa1 mouse embryonic fibroblasts with an EC₅₀ of 0.67-1.2 μM^[1].
dsNec-1 (5-50 μM; ~12 h) does not inhibit TNF/ZVAD.FMK-induced necroptosis in L929 mouse embryonic fibroblasts at concentrations up to 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L929 mouse embryonic fibroblasts
Concentration:

5-50 μM
Incubation Time:

~12 h
Result:

Showed no ability to rescue cells from TNF/ZVAD.FMK-induced necroptosis at either 5 μM or 50 μM, with cell viability remaining near 0%.

Chemical Information

CAS No. 200804-78-0
Molecular Weight 257.31
Formula C₁₃H₁₁N₃OS
SMILES

S=C(N/C(C1=O)=C\C2=CNC3=CC=CC=C32)N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Al-Farhan A, et al. Suppression of Lipid Peroxidation by Necrostatins and Their Potential for Dual Targeting of Ferroptosis and Necroptosis. Journal of medicinal chemistry. 2026 Jul 23;69(14):17508-17523. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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