EGFR-IN-195

Cat. No.: HY-181251: Data Sheet Handling Instructions
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EGFR-IN-195 is a EGFR inhibitor with an IC₅₀ of 0.89 nM. EGFR-IN-195 inhibits the viability of breast cancer cells. EGFR-IN-195 can be used in breast cancer-related research.

For research use only. We do not sell to patients.

EGFR-IN-195 Chemical Structure

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Biological Activity
Purity & Documentation
References
Customer Review

Description

EGFR-IN-195 is a EGFR inhibitor with an IC₅₀ of 0.89 nM. EGFR-IN-195 inhibits the viability of breast cancer cells. EGFR-IN-195 can be used in breast cancer-related research^[1].

In Vitro

EGFR-IN-195 (Compound 5F) (0.5-2 mM; 24 h) potently inhibits the viability of MCF-7 and MDA-MB231 breast cancer cells with IC₅₀ values of 3.96 μM and 4.50 μM, respectively, but exerts no significant effect on normal MCF-10A breast cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	MCF-7, MDA-MB231, MCF-10A
Concentration:	several doses, such as 0.5, 1, and 2 mM
Incubation Time:	24 h
Result:	Exhibited potent cytotoxicity against MCF-7 cells with an IC₅₀ of 3.96 μM. Exhibited potent cytotoxicity against MDA-MB231 cells with an IC₅₀ of 4.50 μM. Showed minimal cytotoxicity against normal MCF-10A cells with an IC₅₀ of 96.70 μM.

Molecular Weight

434.47

Formula

C₂₁H₁₈N₆O₃S

SMILES

O=C1N(CC2=NN=C3SCC(C4=CC(OC)=CC(OC)=C4)=NN32)C5=C(C=CC=C5)N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vasavi Katti, et al. Design and Synthesis of New 1,2,4-Triazolo-
Thiadiazine-Quinoxalin-2(1H)-One Conjugates as
EGFR Targeting Agents. Polycyclic Aromatic Compounds, 1–17.

EGFR-IN-195 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-195EGFREpidermal growth factor receptorErbB-1HER1EGFR inhibitorMCF-7 cellsMDA-MB231 cellsbreast cancerInhibitorinhibitorinhibit

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