EGFR-IN-195
EGFR-IN-195 is a EGFR inhibitor with an IC50 of 0.89 nM. EGFR-IN-195 inhibits the viability of breast cancer cells. EGFR-IN-195 can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- Formula: C21H18N6O3S
- Molecular Weight:434.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
EGFR-IN-195 (Compound 5F) (0.5-2 mM; 24 h) potently inhibits the viability of MCF-7 and MDA-MB231 breast cancer cells with IC50 values of 3.96 μM and 4.50 μM, respectively, but exerts no significant effect on normal MCF-10A breast cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7, MDA-MB231, MCF-10A
-
Concentration:several doses, such as 0.5, 1, and 2 mM
-
Incubation Time:24 h
-
Result:Exhibited potent cytotoxicity against MCF-7 cells with an IC50 of 3.96 μM.
Exhibited potent cytotoxicity against MDA-MB231 cells with an IC50 of 4.50 μM.
Showed minimal cytotoxicity against normal MCF-10A cells with an IC50 of 96.70 μM.
Chemical Information
-
Molecular Weight 434.47
-
Formula C21H18N6O3S
-
SMILES
O=C1N(CC2=NN=C3SCC(C4=CC(OC)=CC(OC)=C4)=NN32)C5=C(C=CC=C5)N=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-195 Related Classifications
HY-181251 Related Classifications
Powered by Bioz