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Cat. No.: HY-111752R

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EML4-ALK K_inase inhibitor 1 (Standard)

EML4-ALK K_inase inhibitor 1 (Standard) is the analytical standard of EML4-ALK K_inase inhibitor 1 (HY-111752). This product is intended for research and analytical applications. EML4-ALK K_inase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma K_inase (EML4-ALK), with an IC₅₀ of 1 nM.

For research use only. We do not sell to patients.

CAS No.: 1373409-08-5
Formula: C₃₁H₄₈N₈O₃
Molecular Weight:580.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EML4-ALK K_inase inhibitor 1 (Standard) Chemical Structure

CAS No.: 1373409-08-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1373409-08-5
Molecular Weight 580.76
Formula C₃₁H₄₈N₈O₃
SMILES

CO[C@H]1CC[C@H](NC2=C(CC)N=C(C(N)=O)C(NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-1692.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EML4-ALK K_inase inhibitor 1 (Standard)

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