Casq1 - calsequestrin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 686019

Summary

Enables calcium ion binding activity. Involved in several processes, including regulation of sequestering of calcium ion; response to denervation involved in regulation of muscle adaptation; and skeletal muscle tissue development. Located in I band; T-tubule; and terminal cisterna lumen. Colocalizes with Golgi apparatus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Casq1 Products (1)

mRNA Protein Name
NM_001159594.1 NP_001153066.1 calsequestrin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
19029185 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of sequestering of calcium ion IDA
IDA: Inferred from direct assay
19029185 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
15138610 RGD
involved in response to muscle inactivity IEP
IEP: Inferred from expression pattern
11546666 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
8600158 RGD
Cellular Component GO Annotation Evidence References Source
located in I band IDA
IDA: Inferred from direct assay
15684334 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
11010809 RGD
located in myofibril IDA
IDA: Inferred from direct assay
15684334 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15684334 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
19029185 RGD
located in terminal cisterna IDA
IDA: Inferred from direct assay
11010809 RGD
located in terminal cisterna lumen IDA
IDA: Inferred from direct assay
6355123 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calsequestrin-1

  • Aspartactin

  • Laminin-binding protein

  • calsequestrin 1 (fast-twitch, skeletal muscle)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01972 CASQ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19990 Casq1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26494 Casq1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casq1 NCBI NCBI:844