TOX - thymocyte selection associated high mobility group box Gene

Also Known as TOX1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9760

About TOX

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,805,412-59,119,147 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 9.9), brain (RPKM 6.2) and 19 other tissues.

Summary

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

TOX Products (1)

mRNA Protein Name
NM_014729.3 NP_055544.1 thymocyte selection-associated high mobility group box protein TOX

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
21126536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (261 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

thymocyte selection-associated high mobility group box protein TOX

  • thymus high mobility group box protein TOX

TOX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TOX O94900 KRTAP12-1 Homo sapiens P59990
Validated Y2H
32296183
Intra
TOX O94900 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
TOX O94900 GRAP Homo sapiens Q13588
Validated Y2H
32296183
Intra
TOX O94900 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
TOX O94900 DMRTB1 Homo sapiens Q96MA1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polycystic Echinococcosis

  • Human Polycystic Hydatid Disease

  • Neotropical Echinococcosis
Astigmatism
Parapsoriasis

  • Digitate Dermatosis

  • Parapsoriasis En Plaque

  • Parapsoriasis En Plaques
Sezary'S Disease

  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176244 KI-TOX-A3 Inhibitor 99.15% Unkown
HY-D0876 POPSO 95.0% Unkown
HY-RS14908 TOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14909 TOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14910 TOX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14911 TOX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17002 Tox Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22349 Tox3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23445 Tox Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28871 Tox3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TOX VGNC VGNC:36228
Canis familiaris TOX VGNC VGNC:47717
Rattus norvegicus TOX RGD RGD:1310455
Felis catus TOX VGNC VGNC:66458
Mus musculus TOX MGD MGI:2181659
Macaca mulatta TOX VGNC VGNC:79165
Others TOX NCBI