ADAP1 - ArfGAP with dual PH domains 1 Gene

Also Known as GCS1L; CENTA1; p42IP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11033

About ADAP1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:897,900-955,407 (from NCBI)

This gene has 19 transcripts (splice variants), 262 orthologues and 28 paralogues. Broad expression in brain (RPKM 18.4), colon (RPKM 17.8) and 18 other tissues.

Summary

Enables GTPase activator activity. Involved in regulation of GTPase activity. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADAP1 Products (5)

mRNA Protein Name
NM_001284308.2 NP_001271237.2 arf-GAP with dual PH domain-containing protein 1 isoform 2
NM_001284309.2 NP_001271238.2 arf-GAP with dual PH domain-containing protein 1 isoform 3
NM_001284310.2 NP_001271239.2 arf-GAP with dual PH domain-containing protein 1 isoform 3
NM_001284311.2 NP_001271240.2 arf-GAP with dual PH domain-containing protein 1 isoform 4
NM_006869.4 NP_006860.2 arf-GAP with dual PH domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
10333475 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12893243 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
10333475 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10333475 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10333475 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10333475 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAP1 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (8 - 119)

PH_11

PH_11: Pleckstrin homology domain (255 - 353)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

arf-GAP with dual PH domain-containing protein 1

  • centaurin-alpha

ADAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
ADAP1 O75689 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
ADAP1 O75689 DVL3 Homo sapiens Q92997
Y2H Array
25416956
Intra
ADAP1 O75689 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
ADAP1 O75689 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
X-Ray Diffraction
21057110
Intra
ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
Pull Down
21057110
Intra
ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
GMS
21057110
Intra
ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
ITC
21057110
Cross: Cross-species interaction Intra: Intraspecies interaction

ADAP1 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P83867 ADAP1 Antibody (YA3564) WB, FC, ELISA Human, Rat
HY-P83867A ADAP1 Antibody (YA3564)(PBS only) WB, FC, ELISA Human, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00315 ADAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADAP1 VGNC VGNC:69429
Rattus norvegicus ADAP1 RGD RGD:621418
Canis familiaris ADAP1 VGNC VGNC:37610
Mus musculus ADAP1 MGD MGI:2442201
Bos taurus ADAP1 VGNC VGNC:25633
Felis catus ADAP1 VGNC VGNC:59604