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KIF13B - kinesin family member 13B Gene

Also Known as GAKIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23303

About KIF13B

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:29,067,278-29,263,388 (from NCBI)

This gene has 6 transcripts (splice variants), 277 orthologues and 41 paralogues. Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity and protein kinase binding activity. Involved in regulation of axonogenesis. Located in axon and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

KIF13B Products (1)

mRNA	Protein	Name
NM_015254.4	NP_056069.2	kinesin-like protein KIF13B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	20194617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10859302	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10859302	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of axonogenesis	IDA IDA: Inferred from direct assay	20194617	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	20194617	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10859302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF13B Protein Structure

Kinesin

FHA

KIF1B

DUF3694

CAP_GLY

0
300
600
900
1200
1500
1826 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF13B	guanylate kinase associated kinesin

KIF13B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF13B	Q9NQT8	DLG1	Homo sapiens	Q12959-2	Pull Down	10859302

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 84a	DFNB84A Deafness, Autosomal Recessive 84 Autosomal Recessive Nonsyndromic Deafness 84a Dfnb84 Deafness, Autosomal Recessive 84a, With Vestibular Dysfunction Autosomal Recessive Deafness 84a Autosomal Recessive Deafness 84a With Vestibular Dysfunction Deafness, Autosomal Recessive, 84a Deafness Autosomal Recessive 84 Deafness Autosomal Recessive 84a With Vestibular Dysfunction Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 84 Deafness, Autosomal Recessive, Type 84a
Meester-Loeys Syndrome	MRLS
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07260	KIF13B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KIF13B	VGNC	VGNC:42382
Bos taurus	KIF13B	VGNC	VGNC:30582
Mus musculus	KIF13B	MGD	MGI:1098265
Macaca mulatta	KIF13B	VGNC	VGNC:99471
Rattus norvegicus	KIF13B	RGD	RGD:1303307
Felis catus	KIF13B	VGNC	VGNC:82484