2. Apoptosis
  3. Ferroptosis
  4. Ferroptosis inducer-5

Ferroptosis inducer-5 (compund 20a) is a ferroptosis inducer.

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Ferroptosis inducer-5

Ferroptosis inducer-5 Chemical Structure

CAS No. : 3043764-74-2

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Description

Ferroptosis inducer-5 (compund 20a) is a ferroptosis inducer[1].

IC50 & Target

Ferroptosis[1]
Cellular Effect
Cell Line Type Value Description References
HT-1080 CC50
0.14 μM
Compound: 20a
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
MDA-MB-231 CC50
0.23 μM
Compound: 20a
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
MEF CC50
0.12 μM
Compound: 20a
Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
NCI-H522 CC50
0.17 μM
Compound: 20a
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
NCI-H522 CC50
0.26 μM
Compound: 20a
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
NCI-H522 CC50
1.59 μM
Compound: 20a
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
U2OS CC50
7.26 μM
Compound: 20a
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
WI-38 CC50
1.53 μM
Compound: 20a
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
[PMID: 39264826]
Molecular Weight

318.35

Formula

C15H14N2O4S
CAS No.
SMILES

CC1=C(C2=CSC(C#C)=N2)C/C(C1OC(C)=O)=N\OC(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ferroptosis inducer-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-53043764-74-2Ferroptosis inducer5Ferroptosis inducer 5FerroptosisInhibitorinhibitorinhibit

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