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Cat. No.: HY-171306

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MK16

Name: MK16
Brand: MedChemExpress
SKU: HY-171306
Price: 580.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research.

For research use only. We do not sell to patients.

Purity: 99.86%
Formula: C₅₅H₉₁ClF₂N₂O₇S
Molecular Weight:997.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK16 Chemical Structure

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

MK16 BLNPs (0.01 mg/mL; 18-24 h) potently deliver mRNA to N2a and bEnd.3 cells in vitro with negligible cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK16 (MK16 BLNP-GFP mRN) (0.5-1.0 mg/kg; i.v.) deliver mRNA to mouse brain tissue with high efficiency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Oil
Molecular Weight 997.84
Formula C₅₅H₉₁ClF₂N₂O₇S
Color Colorless to off-white
SMILES

CC(OCCCCCC)OCCCCCCN(CCCCCCOC(C)OCCCCCC)CCCCCCNC(CC[C@H]1CC[C@@](C2=CC(F)=CC=C2F)(S(C3=CC=C(Cl)C=C3)(=O)=O)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (100.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0022 mL

5.0108 mL

10.0216 mL

5 mM

0.2004 mL

1.0022 mL

2.0043 mL

10 mM

0.1002 mL

0.5011 mL

1.0022 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nat Mater. 2025;24(10):1653-1663. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0022 mL	5.0108 mL	10.0216 mL	25.0541 mL
	5 mM	0.2004 mL	1.0022 mL	2.0043 mL	5.0108 mL
	10 mM	0.1002 mL	0.5011 mL	1.0022 mL	2.5054 mL
	15 mM	0.0668 mL	0.3341 mL	0.6681 mL	1.6703 mL
	20 mM	0.0501 mL	0.2505 mL	0.5011 mL	1.2527 mL
	25 mM	0.0401 mL	0.2004 mL	0.4009 mL	1.0022 mL
	30 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8351 mL
	40 mM	0.0251 mL	0.1253 mL	0.2505 mL	0.6264 mL
	50 mM	0.0200 mL	0.1002 mL	0.2004 mL	0.5011 mL
	60 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.4176 mL
	80 mM	0.0125 mL	0.0626 mL	0.1253 mL	0.3132 mL
	100 mM	0.0100 mL	0.0501 mL	0.1002 mL	0.2505 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

MK16

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MK16 Related Classifications

HY-171306 Related Classifications

Bioz