NCAPG2 - non-SMC condensin II complex subunit G2 Gene

Also Known as 3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54892

About NCAPG2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:158,631,169-158,704,804 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues.

Summary

This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during Mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

NCAPG2 Products (3)

mRNA	Protein	Name
NM_001281932.2	NP_001268861.1	condensin-2 complex subunit G2 isoform a
NM_001281933.2	NP_001268862.1	condensin-2 complex subunit G2 isoform b
NM_017760.7	NP_060230.5	condensin-2 complex subunit G2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	20622854	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17268547	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAPG2 Protein Structure

Condensin2nSMC

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1000
1143 a.a.

Protein Preferred Names	Protein Names
condensin-2 complex subunit G2	chromosome-associated protein G2

Related Diseases

Diseases	Alias
Khan-Khan-Katsanis Syndrome	3KS 3k Syndrome
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09069	NCAPG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NCAPG2	VGNC	VGNC:63733
Macaca mulatta	NCAPG2	VGNC	VGNC:75003
Bos taurus	NCAPG2	VGNC	VGNC:31904
Rattus norvegicus	NCAPG2	RGD	RGD:1308406
Mus musculus	NCAPG2	MGD	MGI:1923294
Canis familiaris	NCAPG2	VGNC	VGNC:43642