RO-7
RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
For research use only. We do not sell to patients.
- CAS No.: 1370241-45-4
- Formula: C24H20F3N3O3S
- Molecular Weight:487.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
11.9 μM
Compound: 76; RO-7
|
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
|
[PMID: 28118010] |
| MDCK | CC50 |
86.2 μM
Compound: 76; RO-7
|
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
|
[PMID: 28118010] |
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1370241-45-4
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Molecular Weight 487.49
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Formula C24H20F3N3O3S
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SMILES
O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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