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RBAK - RB associated KRAB zinc finger Gene

Also Known as ZNF769

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57786

About RBAK

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,045,860-5,069,487 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and 174 paralogues. Ubiquitous expression in thyroid (RPKM 4.0), lymph node (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

RBAK Products (2)

mRNA	Protein	Name
NM_001204456.2	NP_001191385.1	RB-associated KRAB zinc finger protein
NM_021163.4	NP_066986.1	RB-associated KRAB zinc finger protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBAK Protein Structure

KRAB

zf-H2C2_2

zf-C2H2_6

zf-H2C2_2

0
200
400
600
714 a.a.

Protein Preferred Names	Protein Names
RB-associated KRAB zinc finger protein	RB-associated KRAB repressor

RBAK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBAK	Q9NYW8	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	RBAK	Q9NYW8	SLC25A10	Homo sapiens	Q9UBX3-2	Validated Y2H	32296183
Intra	RBAK	Q9NYW8	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	32296183
Intra	RBAK	Q9NYW8	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11715	RBAK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBAK	RGD	RGD:1562875
Canis familiaris	RBAK	VGNC	VGNC:59397
Bos taurus	RBAK	VGNC	VGNC:50045
Mus musculus	RBAK	MGD	MGI:1927369
Others	RBAK	NCBI