Referencia número: HY-B0891

17α-Hydroxyprogesterone

(Synonyms: 17-Hydroxyprogesterone; 17-OHP)

5 Cited Publications

Revisión del cliente

Based on 5 publication(s) in Google Scholar

17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension.

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Pureza: 99.63%
No. CAS: 68-96-2
Fòrmula: C₂₁H₃₀O₃
Peso molecular:330.46

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

17α-Hydroxyprogesterone Chemical Structure

No. CAS: 68-96-2

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (5)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Human Endogenous Metabolite

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vivo

17α-Hydroxyprogesterone (10-100 nmol/crab; injection; injection on days 1, 7, 14, 21 and 28; administration cycle 28 days) significantly increased the mean oocyte diameter, mean ovarian index and ovarian vitellogenin content in female crabs (Oziotelphusa senex senex)^[1].
17α-Hydroxyprogesterone (1 mg/h; 5 days) increased systolic and diastolic blood pressure in sheep^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 68-96-2
Appearance Solid
Peso molecular 330.46
Fòrmula C₂₁H₃₀O₃
Color White to off-white
SMILES

CC([C@@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
Synonyms

17-Hydroxyprogesterone; 17-OHP
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

Publications (5)

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Journal Impact Factor

Nat Commun

Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors. [Abstract]

2024 Oct 8;15(1):8708. PMID: 39379362
Nat Chem Biol

Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. [Abstract]

2022 Nov;18(11):1196-1203. PMID: 35982227
Gut Microbes

Gut microbiota signatures in primary aldosteronism and functional identification of an aldosterone-degrading gut bacterium. [Abstract]

2026 Dec 31;18(1):2657047. PMID: 41964107
Sci Rep

Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy. [Abstract]

2025 Mar 11;15(1):8409. PMID: 40069295
Mol Cell Endocrinol

Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids. [Abstract]

2023 Jun 15:570:111929. PMID: 37037411

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (151.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0261 mL

15.1304 mL

30.2609 mL

5 mM

0.6052 mL

3.0261 mL

6.0522 mL

10 mM

0.3026 mL

1.5130 mL

3.0261 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (278 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Reddy P R, et al. 17α-Hydroxyprogesterone induced ovarian growth and vitellogenesis in the freshwater rice field crab Oziotelphusa senex senex. Aquaculture, 2006, 254(1-4): 768-775.

[2]. Coghlan J P, et al. Hypertensive effect of 17α, 20α7–dihydroxyprogesterone and 17α-hydroxyprogesterone in the sheep. Nature, 1976, 263(5578): 608-609.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0261 mL	15.1304 mL	30.2608 mL	75.6521 mL
	5 mM	0.6052 mL	3.0261 mL	6.0522 mL	15.1304 mL
	10 mM	0.3026 mL	1.5130 mL	3.0261 mL	7.5652 mL
	15 mM	0.2017 mL	1.0087 mL	2.0174 mL	5.0435 mL
	20 mM	0.1513 mL	0.7565 mL	1.5130 mL	3.7826 mL
	25 mM	0.1210 mL	0.6052 mL	1.2104 mL	3.0261 mL
	30 mM	0.1009 mL	0.5043 mL	1.0087 mL	2.5217 mL
	40 mM	0.0757 mL	0.3783 mL	0.7565 mL	1.8913 mL
	50 mM	0.0605 mL	0.3026 mL	0.6052 mL	1.5130 mL
	60 mM	0.0504 mL	0.2522 mL	0.5043 mL	1.2609 mL
	80 mM	0.0378 mL	0.1891 mL	0.3783 mL	0.9457 mL
	100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7565 mL

Keywords

17α-Hydroxyprogesterone

5 Cited Publications

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17α-Hydroxyprogesterone

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Publications Citing Use of MedChemExpress (MCE) 17α-Hydroxyprogesterone

Ver todos los productos específicos de isoformas Endogenous Metabolite

Actividad biológica

Chemical Information

Publications (5)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

17α-Hydroxyprogesterone Related Classifications

HY-B0891 Related Classifications