17α-Hydroxyprogesterone-d8
Based on 1 Customer Validation
17α-Hydroxyprogesterone-d8 is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.52%
- CAS No.: 850023-80-2
- Formule: C21H22D8O3
- Masse moléculaire:338.51
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-15772A
Osimertinib mesylate -
HY-113263R
17a-Hydroxypregnenolone (Standard) -
HY-113263S
17a-Hydroxypregnenolone-d3 -
HY-14959
Ulipristal -
HY-B0521
Altrenogest -
HY-13071
Nestoron -
HY-A0285
Norethisterone enanthate -
HY-15606
Tanaproget -
HY-N0437S
Progesterone-d9 -
HY-B0151S2
Pregnenolone-d4-1 -
HY-B0648S
Medroxyprogesterone-d3 -
HY-B0521R
Altrenogest (Standard)
Voir tous les produits spécifiques à Isoform Endogenous Metabolite
More
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 850023-80-2
-
Unlabeled CAS 68-96-2
-
Appearance Solid
-
Masse moléculaire 338.51
-
Formule C21H22D8O3
-
Color White to off-white
-
SMILES
C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])[2H])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C
-
Synonyms
17-Hydroxyprogesterone-d8; 17-OHP-d8
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (147.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 0.1 mg/mL (0.30 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.69 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
-
Fiche technique (278 KB)
-
SDS (799 KB)
- English - EN (799 KB)
- Français - FR (799 KB)
- Deutsch - DE (799 KB)
- Norwegian - NO (799 KB)
- Español - ES (799 KB)
- Swedish - SV (799 KB)
- Italian - IT (799 KB)
- Korean - KR (799 KB)
- Portuguese - PT (799 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9541 mL | 14.7706 mL | 29.5412 mL | 73.8531 mL |
| 5 mM | 0.5908 mL | 2.9541 mL | 5.9082 mL | 14.7706 mL | |
| 10 mM | 0.2954 mL | 1.4771 mL | 2.9541 mL | 7.3853 mL | |
| 15 mM | 0.1969 mL | 0.9847 mL | 1.9694 mL | 4.9235 mL | |
| 20 mM | 0.1477 mL | 0.7385 mL | 1.4771 mL | 3.6927 mL | |
| 25 mM | 0.1182 mL | 0.5908 mL | 1.1816 mL | 2.9541 mL | |
| 30 mM | 0.0985 mL | 0.4924 mL | 0.9847 mL | 2.4618 mL | |
| 40 mM | 0.0739 mL | 0.3693 mL | 0.7385 mL | 1.8463 mL | |
| 50 mM | 0.0591 mL | 0.2954 mL | 0.5908 mL | 1.4771 mL | |
| 60 mM | 0.0492 mL | 0.2462 mL | 0.4924 mL | 1.2309 mL | |
| 80 mM | 0.0369 mL | 0.1846 mL | 0.3693 mL | 0.9232 mL | |
| 100 mM | 0.0295 mL | 0.1477 mL | 0.2954 mL | 0.7385 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
17α-Hydroxyprogesterone-d8 Related Classifications
HY-B0891S Related Classifications
Powered by Bioz