BRD7116
Based on 1 Customer Validation
BRD7116 is a cell-non-autonomous inhibitor of leukemic stem cells (LSCs). BRD7116, without directly contacting LSCs, can inhibit LSCs merely by altering the microenvironment. BRD7116 also has any cell-autonomous effects on LSCs and induces transcriptional changes consistent with myeloid differentiation. BRD7116 can be used for the study of leukemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.89%
- No. CAS: 329059-55-4
- Fòrmula: C28H36N2O4S
- Peso molecular:496.66
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
BRD7116 (0.0625-16 μM) shows activity against LSCes (the LSC-enriched fraction of cells) (EC50 = 200 nM) and patient-derived, primary human leukemia cells, and displays limited activity against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines[1].
BRD7116 (0-15 μM, 3 d) pretreatment of the stroma preferentially inhibits the LSCe cells compared to HSPCs[1].
BRD7116 (5 μM, 6 h) induced transcriptional changes consistent with myeloid differentiation in LSCes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 329059-55-4
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Appearance Solid
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Peso molecular 496.66
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Fòrmula C28H36N2O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : ≥ 48 mg/mL (96.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0134 mL | 10.0672 mL | 20.1345 mL | 50.3362 mL |
| 5 mM | 0.4027 mL | 2.0134 mL | 4.0269 mL | 10.0672 mL | |
| 10 mM | 0.2013 mL | 1.0067 mL | 2.0134 mL | 5.0336 mL | |
| 15 mM | 0.1342 mL | 0.6711 mL | 1.3423 mL | 3.3557 mL | |
| 20 mM | 0.1007 mL | 0.5034 mL | 1.0067 mL | 2.5168 mL | |
| 25 mM | 0.0805 mL | 0.4027 mL | 0.8054 mL | 2.0134 mL | |
| 30 mM | 0.0671 mL | 0.3356 mL | 0.6711 mL | 1.6779 mL | |
| 40 mM | 0.0503 mL | 0.2517 mL | 0.5034 mL | 1.2584 mL | |
| 50 mM | 0.0403 mL | 0.2013 mL | 0.4027 mL | 1.0067 mL | |
| 60 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8389 mL | |
| 80 mM | 0.0252 mL | 0.1258 mL | 0.2517 mL | 0.6292 mL |
BRD7116 Related Classifications
HY-18714 Related Classifications
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