A-348441
A-348441 is a liver selective glucocorticoid receptor antagonist. A-348441 can reduce the glucose level in the liver. A-348441 can be used for the research of metabolic disease, such as type 2 diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 639520-46-0
- Fòrmula: C54H75NO7
- Peso molecular:850.18
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
10 nM
Compound: 2
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Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay
Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay
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[PMID: 16987661] |
Chemical Information
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No. CAS 639520-46-0
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Peso molecular 850.18
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Fòrmula C54H75NO7
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SMILES
C[C@@]12[C@](CC[C@@]2(O)C#CC)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)CCO[C@@H]5C[C@]6([H])[C@@](C)([C@]7([H])[C@@]([C@@]8([H])[C@@](C)([C@]([C@H](C)CCC(O)=O)([H])CC8)[C@@H](O)C7)([H])[C@H](O)C6)CC5)C=C4)C1)=C9C(CC3)=CC(CC9)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-348441 Related Classifications
HY-108061 Related Classifications
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