BMS-694153
BMS-694153 is a potent antagonist of the human calcitonin gene-related peptide receptor (CGRP Receptor). BMS-694153 can be used for migraine with rapid and efficient intranasal exposure.
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- No. CAS: 1050381-35-5
- Fòrmula: C35H45FN8O3
- Peso molecular:644.78
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-N-MC | EC50 |
0.0345 nM
Compound: 4, BMS-694153
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Antagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
Antagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
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[PMID: 18665579] |
| SK-N-MC | IC50 |
0.026 nM
Compound: 1, (BMS-694153)
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Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
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[PMID: 23993336] |
Chemical Information
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No. CAS 1050381-35-5
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Peso molecular 644.78
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Fòrmula C35H45FN8O3
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SMILES
O=C1N(C2CCN(CC2)C(N[C@@H](C(N3CCC(N4CCCCC4)CC3)=O)CC5=CC(C)=C(NN=C6)C6=C5)=O)CC7=CC=CC(F)=C7N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Degnan AP, et al. Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem. 2008 Aug 28;51(16):4858-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-694153 Related Classifications
HY-114574 Related Classifications
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