Cellohexaose
Based on 1 Customer Validation
Cellohexaose is a YKL-40 carbohydrate-binding ligand that occupies the primary carbohydrate-binding cleft through carbohydrate-π stacking and hydrogen-bonding interactions, and can serve as a bioinert spacer for hybrid glyco-nanolayers, modulating the surface density of bioactive shell hexaose to enhance TLR2-mediated responses. Cellohexaose is used in research on chronic inflammatory diseases and cancer.
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- Pureza : 99.95%
- No. CAS: 2478-35-5
- Fòrmula: C36H62O31
- Peso molecular:990.86
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
Cellohexaose (300 K; 0.1-250 ns) binds to the main binding cleft of YKL-40, with an absolute free energy of -12.6 kJ/mol[1].
Cellohexaose (1.0 mM) interacts with the Au surface via S-Au coordination bonds, achieving a surface density of 0.811 chains nm-2[6].
Cellohexaose (1.0 mM; 24 h) forms a stable self-assembled monolayer on the Au surface[6].
Cellohexaose (1.0 × 105 cells mL-1; 3-120 h) supports the tight adhesion and 2-D proliferation of HepG2 cells, with the growth rate declining after 72 h[6].
Cellohexaose (1 mM; 3 days) supports lower CYP1A1 activity in HepG2 cells than the mixed nanolayer[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:HepG2
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Concentration:1.0 × 105 cells mL-1
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Incubation Time:3, 24, 72 and 120 h
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Result:Proliferated well for 72 h after cell seeding, then growth rates decreased.
After 5 days, exhibited a 2-D form similar to cells on the TCPS plate.
Chemical Information
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No. CAS 2478-35-5
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Appearance Solid
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Peso molecular 990.86
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Fòrmula C36H62O31
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Color White to off-white
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SMILES
O[C@H]1[C@]([C@H](O[C@@H](O[C@]([C@@H]2O)([H])[C@H](O[C@@H](O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)[C@@H]2O)CO)[C@@H]1O)CO)([H])O[C@@H]([C@@H]([C@@H](O)[C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)O)([H])O[C@@H]4CO)O)O[C@@H]3CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cellohexaose Related Classifications
HY-N1915 Related Classifications
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