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Referencia número: HY-137694A

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ddTTP tetrasodium

ddTTP tetrasodium is a DNA polymerase γ inhibitor, with K_i values of 0.05 μM and 0.4 μM against bovine testicular DNA polymerase γ. ddTTP tetrasodium can be incorporated into DNA to cause termination of the extended DNA strand. ddTTP tetrasodium can be used in the research of HIV infection.

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Fòrmula: C₁₀H₁₃N₂Na₄O₁₃P₃
Peso molecular:554.10

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Please store the product under the recommended conditions in the Certificate of Analysis.

ddTTP tetrasodium Chemical Structure

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In Vitro

ddTTP tetrasodium (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a K_i value of 0.05 μM when poly (rA)-oligo (dT) serves as the template-primer^[1].
Tetrasodium ddTTP (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a K_i value of 0.4 μM when activated calf thymus DNA is used as the template-primer^[1].
Tetrasodium ddTTP (2.5-10 μM; 60 min) can be incorporated into DNA by bovine testicular DNA polymerase γ and induce chain termination, and this effect is independent of 3'-exonuclease proofreading activity (verified by treatment with 1 mM 5'-GMP)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 554.10
Fòrmula C₁₀H₁₃N₂Na₄O₁₃P₃
SMILES

O=[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H](O1)CC[C@@H]1N(C(NC2=O)=O)C=C2C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Izuta S, et al. The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms. Biochem Biophys Res Commun. 1991 Sep 16;179(2):776-83. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ddTTP tetrasodium

Ver todos los productos específicos de isoformas DNA/RNA Synthesis

Ver todos los productos específicos de isoformas HIV

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ddTTP tetrasodium Related Classifications

HY-137694A Related Classifications