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Referencia número: HY-189042

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EF1500

EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 738562-57-7
Fòrmula: C₂₁H₂₄N₂O₂S₂
Peso molecular:400.56

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

EF1500 Chemical Structure

No. CAS: 738562-57-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

In Vitro

EF1500 binds effectively to hGAT1, with a binding energy of -9.19 kcal/mol for R-EF1500 to hGAT1 and -8.34 kcal/mol for S-EF1500 to hGAT1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 738562-57-7
Peso molecular 400.56
Fòrmula C₂₁H₂₄N₂O₂S₂
SMILES

O=C1NOC2=C1C(NCCC=C(C=3SC=CC3C)C=4SC=CC4C)CCC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nowaczyk A, et al. Studies on the Activity of Selected Highly Lipophilic Compounds toward hGAT1 Inhibition. Part II. ACS chemical neuroscience. 2019 Jan 16;10(1):337-347.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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