Fonsartan
Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI).
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- No. CAS: 153235-15-5
- Fòrmula: C26H30K2N4O5S2
- Peso molecular:620.87
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Angiotensin Receptor
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Actividad biológica
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AT1 Receptor |
Fonsartan selectively inhibits AT1 receptors (mainly in the adrenal cortex (IC50 = 1.5 × 10-8 M)) while having a lower affinity for AT2 receptors (mainly in the adrenal medulla (IC50 = 1.4 × 10-6 M))[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A myocardial infarction (MI) model was induced in male normotensive Wistar rats (weighing 250-280 g) by ligating the left anterior descending coronary artery[1].
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Dosage:3 mg/kg
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Administration:S.c., once daily for 6 weeks
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Result:Administration at 30 min, 3 h, 24 h, and 7 d post-administration all inhibited myocardial hypertrophy.
Administration at 3 h and 24 h post-administration significantly reduced infarct size.
Limited effect on improving left ventricular dilation (LVD, LVC).
Chemical Information
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No. CAS 153235-15-5
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Peso molecular 620.87
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Fòrmula C26H30K2N4O5S2
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SMILES
O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(N([K])C(NCCC)=O)=O)C=CC=C3)C=C2)O[K]
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Synonyms
HR 720
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Xia QG, et al. Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure. Cardiovasc Res. 2001 Jan;49(1):110-7. [Content Brief]
[2]. Jin D, et al. Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo. Jpn J Pharmacol. 1997 Nov;75(3):259-66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fonsartan Related Classifications
HY-19224 Related Classifications
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