FP1-24
FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1403557-08-3
- Fòrmula: C20H17F2N3O3
- Peso molecular:385.36
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
CK1γ1 40 nM (IC50) |
CK1γ2 10 nM (IC50) |
CK1γ3 10 nM (IC50) |
CK1δ 40 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.2 μM
Compound: 13
|
Inhibition of human CK1-gamma2 in HEK293 cells assessed as inhibition of doxcycline-induced LRP6 phosphorylation after 2 hrs by electrochemiluminescence analysis
Inhibition of human CK1-gamma2 in HEK293 cells assessed as inhibition of doxcycline-induced LRP6 phosphorylation after 2 hrs by electrochemiluminescence analysis
|
[PMID: 24900428] |
FP1-24 (10 μM; 2 h) reduces LRP6 phosphorylation at T1479 in WNT-activated HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1403557-08-3
-
Peso molecular 385.36
-
Fòrmula C20H17F2N3O3
-
SMILES
COC1=CN=C(COC2=CC=C(F)C(F)=C2)C=C1C(N3)=CC4=C3CCNC4=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FP1-24 Related Classifications
HY-181585 Related Classifications
Powered by Bioz