DOCK3 - dedicator of cytokinesis 3 Gene

Also Known as PBP; MOCA; NEDIDHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1795

About DOCK3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:50,674,927-51,384,198 (from NCBI)

This gene has 1 transcript (splice variant), 271 orthologues, 10 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 7.9), thyroid (RPKM 4.0) and 6 other tissues.

Summary

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved Amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

DOCK3 Products (1)

mRNA Protein Name
NM_004947.5 NP_004938.1 dedicator of cytokinesis protein 3

DOCK3 Protein Structure

SH3_2

SH3_2: Variant SH3 domain (10 - 61)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (416 - 609)

DHR-2

DHR-2: Dock homology region 2 (1444 - 1627)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2030 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 3

  • modifier of cell adhesion

DOCK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
DOCK3 Q8IZD9 ARHGAP5 Homo sapiens Q13017-1 32203420
Intra
DOCK3 Q8IZD9 NCK1 Homo sapiens P16333 17474147
Intra
DOCK3 Q8IZD9 PLEKHF2 Homo sapiens Q9H8W4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Impaired Intellectual Development, Hypotonia, And Ataxia
  • NEDIDHA

  • Neurodevelopmental Disorder, Impaired Intellectual Development, Hypotonia, And Ataxia

Hypotonia
Non-Specific Syndromic Intellectual Disability
  • Complex Neurodevelopmental Disorder

Complex Chromosomal Rearrangement
Attention Deficit-Hyperactivity Disorder
  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus DOCK3 VGNC VGNC:50146
Canis familiaris DOCK3 VGNC VGNC:40047
Mus musculus DOCK3 MGD MGI:2429763
Macaca mulatta DOCK3 VGNC VGNC:71967
Felis catus DOCK3 VGNC VGNC:61572
Rattus norvegicus DOCK3 RGD RGD:1306677
Others DOCK3 NCBI