DOCK3 - dedicator of cytokinesis 3 Gene
Also Known as PBP; MOCA; NEDIDHA
Species: Homo sapiens
About DOCK3
This gene has 1 transcript (splice variant), 271 orthologues, 10 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 7.9), thyroid (RPKM 4.0) and 6 other tissues.
Summary
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved Amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
DOCK3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004947.5 | NP_004938.1 | dedicator of cytokinesis protein 3 |
DOCK3 Protein Structure
SH3_2: Variant SH3 domain (10 - 61)
DOCK-C2: C2 domain in Dock180 and Zizimin proteins (416 - 609)
DHR-2: Dock homology region 2 (1444 - 1627)
- 0
- 400
- 800
- 1200
- 1600
- 2030 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
dedicator of cytokinesis protein 3 |
|
DOCK3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Referencias |
|---|---|---|---|---|---|---|---|
|
Intra
|
DOCK3 | Q8IZD9 | ARHGAP5 | Homo sapiens | Q13017-1 | 32203420 | |
|
Intra
|
DOCK3 | Q8IZD9 | NCK1 | Homo sapiens | P16333 | 17474147 | |
|
Intra
|
DOCK3 | Q8IZD9 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurodevelopmental Disorder With Impaired Intellectual Development, Hypotonia, And Ataxia |
|
|
| Hypotonia |
|
|
| Non-Specific Syndromic Intellectual Disability |
|
|
| Complex Chromosomal Rearrangement |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | DOCK3 | VGNC | VGNC:50146 |
| Canis familiaris | DOCK3 | VGNC | VGNC:40047 |
| Mus musculus | DOCK3 | MGD | MGI:2429763 |
| Macaca mulatta | DOCK3 | VGNC | VGNC:71967 |
| Felis catus | DOCK3 | VGNC | VGNC:61572 |
| Rattus norvegicus | DOCK3 | RGD | RGD:1306677 |
| Others | DOCK3 | NCBI |