RPL28 - ribosomal protein L28 Gene

Also Known as L28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6158

About RPL28

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,385,932-55,403,342 (from NCBI)

This gene has 11 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in spleen (RPKM 70.1), ovary (RPKM 68.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

RPL28 Products (6)

mRNA Protein Name
NM_000991.5 NP_000982.2 60S ribosomal protein L28 isoform 2
NM_001136134.1 NP_001129606.1 60S ribosomal protein L28 isoform 1
NM_001136135.2 NP_001129607.1 60S ribosomal protein L28 isoform 3
NM_001136136.1 NP_001129608.1 60S ribosomal protein L28 isoform 4
NM_001136137.1 NP_001129609.1 60S ribosomal protein L28 isoform 5
NM_001363697.1 NP_001350626.1 60S ribosomal protein L28 isoform 6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
20434207 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cell body IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
located in dendrite IDA
IDA: Inferred from direct assay
15121898 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL28 Protein Structure

Ribosomal_L28e

Ribosomal_L28e: Ribosomal L28e protein family (5 - 121)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L28

  • large ribosomal subunit protein eL28

RPL28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
RPL28 P46779 DCC Homo sapiens P43146
Density Sedimentation
20434207
Intra
RPL28 P46779 RPL4 Homo sapiens P36578
Anti Tag CoIP
28514442
Intra
RPL28 P46779 RPL4 Homo sapiens P36578
Crosslink
30021884
Intra
RPL28 P46779 RPL4 Homo sapiens P36578
Anti Tag CoIP
33961781
Intra
RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Intra
RPL28 P46779 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra
RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RPL28 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P810919 RPL28 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia 2

  • DBA2

  • Anemia, Diamond-Blackfan, 2

  • Anemia Diamond-Blackfan 2
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS12182 RPL28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPL28 MGD MGI:101839
Rattus norvegicus RPL28 RGD RGD:621193
Bos taurus RPL28 VGNC VGNC:34114
Canis familiaris RPL28 VGNC VGNC:45717
Others RPL28 NCBI