MKNK1 - MAPK interacting serine/threonine kinase 1 Gene

Also Known as MNK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8569

About MKNK1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,557,407-46,604,268 (from NCBI)

This gene has 31 transcripts (splice variants), 166 orthologues and 6 paralogues. Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues.

Summary

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

MKNK1 Products (31)

mRNA Protein Name
NM_001377373.1 NP_001364302.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3
NM_198973.5 NP_945324.2 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
XM_047433025.1 XP_047288981.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NM_003684.7 NP_003675.3 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1
XM_047433042.1 XP_047288998.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
NM_001377374.1 NP_001364303.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
NR_146512.2
XM_024450510.2 XP_024306278.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
XM_047433081.1 XP_047289037.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9
NM_001377342.1 NP_001364271.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5
XM_047433024.1 XP_047288980.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NR_024175.1
NM_001377375.1 NP_001364304.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
XM_017002660.3 XP_016858149.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7
NM_001377341.1 NP_001364270.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5
XM_047433022.1 XP_047288978.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1
NR_024176.3
XM_047433059.1 XP_047289015.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
XM_047433047.1 XP_047289003.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
NM_001377337.1 NP_001364266.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4
XM_006711002.4 XP_006711065.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3
NM_001377343.1 NP_001364272.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 6
NM_001135553.4 NP_001129025.2 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3
XM_047433053.1 XP_047289009.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
XM_047433066.1 XP_047289022.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6
XM_047433026.1 XP_047288982.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NR_024174.3
NR_165250.1
NM_001377338.1 NP_001364267.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4
XM_047433039.1 XP_047288995.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
XM_047433079.1 XP_047289035.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables ATP binding IDA
IDA: Inferred from direct assay
9155018 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9155018 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9155018 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17130135 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9155018 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MKNK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (52 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

MAP kinase-interacting serine/threonine-protein kinase 1

  • MAP kinase interacting serine/threonine kinase 1

  • MAP kinase signal-integrating kinase 1

  • MAPK signal-integrating kinase 1

MKNK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
MKNK1 Q9BUB5 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
MKNK1 Q9BUB5 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
MKNK1 Q9BUB5 MAPK14 Homo sapiens Q16539
Pull Down
32707033
Intra
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Y2H Array
32296183
Intra
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Y2H Prey Pooling
32296183
Intra
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fragile X Syndrome

  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-RS08473 MKNK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08474 Mknk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08475 Mknk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MKNK1 VGNC VGNC:31491
Macaca mulatta MKNK1 VGNC VGNC:74876
Mus musculus MKNK1 MGD MGI:894316
Canis familiaris MKNK1 VGNC VGNC:54216
Rattus norvegicus MKNK1 RGD RGD:1559603
Felis catus MKNK1 VGNC VGNC:68264
Others MKNK1 NCBI