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Referencia número: HY-119581

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MBED

Name: MBED
Brand: MedChemExpress
SKU: HY-119581
Availability: PreOrder

(Synonyms: 9-Methyl-7-bromoeudistomin D)

MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs.

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No. CAS: 123363-40-6
Fòrmula: C₁₂H₈Br₂N₂O
Peso molecular:356.01

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MBED Chemical Structure

No. CAS: 123363-40-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs^[1]^[2].

Chemical Information

No. CAS 123363-40-6
Peso molecular 356.01
Fòrmula C₁₂H₈Br₂N₂O
SMILES

OC1=C(C2=C(C=C1Br)N(C3=C2C=CN=C3)C)Br
Synonyms

9-Methyl-7-bromoeudistomin D
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Signal Pathway Related

Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca²⁺]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca²⁺ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Diaz-Sylvester PL, et al. Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle. Mol Pharmacol. 2014 Apr;85(4):564-75. [Content Brief]

[2]. Mirko Vukcevic, et al. Downstream Effects of a RyR1 Mutation Linked to Malignant Hyperthermia on the Phenotypic and Functional Characteristic of Dendritic Cells. Volume 102, Issue 3, Supplement 1307aJanuary 31, 2012.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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