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Referencia número: HY-130451

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Misakimycin

Misakimycin is a naphthoquinone compound. Misakimycin exhibits cytotoxicity against human melanoma, breast cancer and ovarian cancer cells. Misakimycin can be found in strains of the genus Pyrenochaetopsis (strain MSX63693). Misakimycin can be used in research related to melanoma, breast cancer and ovarian cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 91776-49-7
Fòrmula: C₁₃H₁₂O₅
Peso molecular:248.23

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Misakimycin Chemical Structure

No. CAS: 91776-49-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	15 μM Compound: 6	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
MDA-MB-435	IC₅₀	3.2 μM Compound: 6	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
OVCAR-3	IC₅₀	9.6 μM Compound: 6	Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]

In Vitro

Misakimycin (72 h) inhibits the growth of human melanoma MDA-MB-435 cells, human breast cancer MDA-MB-231 cells, and human ovarian cancer OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-435, MDA-MB-231, OVCAR3
Concentration:

/
Incubation Time:

72 h
Result:

Had an IC₅₀ of 3.2 μM for MDA-MB-435 cells, 15 μM for MDA-MB-231 cells and 9.6 μM for OVCAR3 cells.

Related Protocols :

Chemical Information

No. CAS 91776-49-7
Peso molecular 248.23
Fòrmula C₁₃H₁₂O₅
SMILES

O=C1C(OC)=CC(C2=C1C=C(OC)C(C)=C2O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Flores-Bocanegra L, et al. Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments. J Nat Prod. 2021;84(3):771-778. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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