P13I
P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.
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- No. CAS: 2360561-66-4
- Fòrmula: C46H48N12O9
- Peso molecular:912.95
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HBL | GI50 |
28 nM
Compound: 74
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Antiproliferative activity against human HBL cells assessed as inhibition of cell growth
Antiproliferative activity against human HBL cells assessed as inhibition of cell growth
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[PMID: 36324498] |
| HBL1 | GI50 |
28 nM
Compound: 24; P13I
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Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition
Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition
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[PMID: 32698111] |
| HBL1 | GI50 |
28 nM
Compound: 49; P131
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Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition
Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition
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[PMID: 35594541] |
| TMD8 | IC50 |
15 nM
Compound: P13I
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Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay
Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay
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[PMID: 37195170] |
Chemical Information
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No. CAS 2360561-66-4
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Peso molecular 912.95
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Fòrmula C46H48N12O9
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SMILES
NC1=NC=NC2=C1C(C3=CC=C(C=C3)OC4=CC=CC=C4)=NN2[C@@H]5CCCN(C5)C(C6=CN(N=N6)CCOCCOCCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P13I Related Classifications
HY-W591307 Related Classifications
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