country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-108327

Copy Link Print Information

PF-05020182

PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC₅₀ of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1354712-92-7
Fòrmula: C₁₈H₃₀N₄O₄
Peso molecular:366.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PF-05020182 Chemical Structure

No. CAS: 1354712-92-7

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1327 nM Compound: 2, PF-05020182	Activation of rat Kv7.3/7.5 expressed in CHOK1 cells Activation of rat Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	294 nM Compound: 2, PF-05020182	Activation of rat Kv7.2/7.3 expressed in CHOK1 cells Activation of rat Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	334 nM Compound: 2, PF-05020182	Activation of human Kv7.2/7.3 expressed in CHOK1 cells Activation of human Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	376 nM Compound: 2, PF-05020182	Activation of rat Kv7.4 expressed in CHOK1 cells Activation of rat Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	588 nM Compound: 2, PF-05020182	Activation of human Kv7.3/7.5 expressed in CHOK1 cells Activation of human Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	625 nM Compound: 2, PF-05020182	Activation of human Kv7.4 expressed in CHOK1 cells Activation of human Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	>100000 nM Compound: 2, PF-05020182	Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells	[PMID: 25987375]

Chemical Information

No. CAS 1354712-92-7
Peso molecular 366.46
Fòrmula C₁₈H₃₀N₄O₄
SMILES

O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4941-4944. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto