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Referencia número: HY-W683866

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Piroheptine

Piroheptine is a muscarinic acetylcholine receptor (mAChR) antagonist and dopamine reuptake inhibitor. Piroheptine blocks the high-affinity dopamine transport system, prevents MPP⁺ uptake into dopaminergic neurons, and exerts anticholinergic activity. Piroheptine completely prevents MPTP (HY-W114750)-induced loss of striatal dopamine and DOPAC, and increases striatal dopamine levels. Piroheptine can be used in studies related to Parkinson's disease.

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No. CAS: 16378-21-5
Fòrmula: C₂₂H₂₅N
Peso molecular:303.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Piroheptine Chemical Structure

No. CAS: 16378-21-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas mAChR :

In Vivo

Piroheptine (20 mg/kg; i.p.; single dose) completely prevents MPTP-induced striatal dopamine and DOPAC depletion in male C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8-week-old, 20-30 g, Parkinsonism induced via 4 intraperitoneal injections of 10 mg/kg MPTP at 1-hour intervals)^[1]
Dosage:

20 mg/kg
Administration:

i.p.; 30 minutes before each of 4 MPTP injections (1 hour apart); single treatment (piroheptine-alone group)
Result:

Completely prevented MPTP-induced striatal dopamine loss, resulting in levels of 9.5 μg/g wet tissue.
Completely prevented MPTP-induced striatal DOPAC loss, resulting in levels of 0.8 μg/g wet tissue.
Increased striatal dopamine content to 10.2 μg/g wet tissue (approximately 10% higher than saline controls) when administered alone.

Chemical Information

No. CAS 16378-21-5
Peso molecular 303.45
Fòrmula C₂₂H₂₅N
SMILES

C=1C=CC2=C(C1)C(C=3C=CC=CC3CC2)=C4CCN(CC)C4C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Saitoh T, et al. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. Journal of the neurological sciences. 1988 Feb;83(2-3):161-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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