Piroxantrone
Piroxantrone (Oxantrazole) is a potent DNA topoisomerase II-targeting anthrapyrazole antitumor agent. Piroxantrone displays cardiotoxicity.
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- No. CAS: 91441-23-5
- Fòrmula: C21H25N5O4
- Peso molecular:411.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
4 μM
Compound: Piroxantrone
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Growth inhibition of human K562 cells after 72 hrs by MTS method
Growth inhibition of human K562 cells after 72 hrs by MTS method
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[PMID: 18258442] |
Chemical Information
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No. CAS 91441-23-5
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Peso molecular 411.45
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Fòrmula C21H25N5O4
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SMILES
O=C1C2=C3C(N(N=C3C4=C(C=CC(O)=C14)O)CCNCCO)=CC=C2NCCCN
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Synonyms
Oxantrazole; NCS 349174
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Hasinoff BB, et al. The displacement of iron(III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotective agent dexrazoxane. J Inorg Biochem. 1999 Nov-Dec;77(3-4):257-9. [Content Brief]
[2]. Frank SK, et al. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone). Cancer Chemother Pharmacol. 1989;23(4):213-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piroxantrone Related Classifications
HY-13726 Related Classifications
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