PW507
PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a Ki of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2573850-59-4
- Fòrmula: C18H27ClN4
- Peso molecular:334.89
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Sigma Receptor
More
Actividad biológica
Descripciòn
In Vitro
PW507 binds to the orthosteric site of the human S1R crystal structure and engages in strong interactions with the receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PW507’s Pharmacokinetic Properties in SD rats Studies[1].
| plasma PK | IV | PO | IP |
| dose (mg/kg) | 1 | 25 | 10 |
| tmax (h) | N/A | 1.20 | 0.25 |
| t1/2 (h) | 0.53 | 0.69 | 0.56 |
| Cmax (ng/mL) | 193 | 296 | 671 |
| AUC0-inf (h*ng/mL) | 108 | 692 | 552 |
| CL (mL/min/kg) | 155 | N/A | N/A |
| ratio (brain/plasma, t = 0.25 h) | N/A | N/A | 12 |
| F (%) | 100 | 28 | 51 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male SD rats injected Streptozotocin (HY-13753; STZ; 60 mg/kg)[1]
-
Dosage:20 mg/kg
-
Administration:i.p; twice daily; for 14 days
-
Result:Demonstrated significant efficacy in alleviating mechanical allodynia hyperalgesia.
Chemical Information
-
No. CAS 2573850-59-4
-
Peso molecular 334.89
-
Fòrmula C18H27ClN4
-
SMILES
CC(C)(C)C1=CC=C(C2=NC(CN3CCCC3)=NN2C)C=C1.Cl
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PW507 Related Classifications
HY-161873 Related Classifications
Powered by Bioz