RNA binder 1
RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD).
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- No. CAS: 3105281-39-5
- Fòrmula: C22H20N10S2
- Peso molecular:488.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 3105281-39-5
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Peso molecular 488.59
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Fòrmula C22H20N10S2
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SMILES
NC(N/N=C/C1=CC=CC(C2=CC=C(S2)C3=CC=C(S3)C4=CC=CC(/C=N/NC(N)=N)=N4)=N1)=N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RNA binder 1 Related Classifications
HY-172902 Related Classifications
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