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United States

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Referencia número: HY-P4096B

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scHAP-1

scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₆₀H₉₀N₁₈O₁₇
Peso molecular:1335.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

scHAP-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

In Vivo

Animal Model:

Wistar rats (female; adjuvant-induced arthritis model)^[1]
Dosage:

0.5 mg drug/0.5 ml/250 g rat/day
Administration:

i.v.; two consecutive days
Result:

Showed a 9-fold increase in fluorescence signal in arthritic joints compared to unaffected joints in the same animals at 3 hours post-injection.

Related Protocols :

Chemical Information

Peso molecular 1335.47
Fòrmula C₆₀H₉₀N₁₈O₁₇
Sequence

Ala-Leu-Ser-Gln-Ala-Phe-Arg-His-Ala-Phe-Thr-Ser
Sequence Shortening

ALSQAFRHAFTS
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Vanniasinghe AS, et al. Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clin Immunol. 2014;151(1):43-54. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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