2 Results for "

classical complement cascade

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "classical complement cascade" in MCE Product Catalog:

5
Tanruprubart
Tanruprubart
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5 Cited Publications
Referencia número: HY-P990545
No. CAS: 2065212-40-8
Synonyms: ANX005

Target:  

Complement System

Áreas de investigación:  

Neurological Disease

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG4 kappa, Isotype Control (HY-P99003). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .
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Vonaprument
Vonaprument
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Referencia número: HY-P992142
No. CAS: 3050549-24-8
Synonyms: ANX-007

Target:  

Complement System

Áreas de investigación:  

Neurological Disease Metabolic Disease

Vonaprument (ANX-007) is an intravitreally injected C1q antibody fragment (with a molecular weight of approximately 48 kDa) and a human monoclonal antibody. Vonaprument inhibits the activation of the classical complement cascade by specifically recognizing the globular head of C1q and blocking substrate binding. After intravitreal injection, Vonaprument distributes to the retina, choroid and optic nerve, and achieves complete C1q target binding in the aqueous humor and retinal tissues. Vonaprument can be used in research related to neurodegenerative eye diseases such as age-related macular degeneration and glaucoma .
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