Transfluthrin
Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. Transfluthrin acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 118712-89-3
- Fòrmula: C15H12Cl2F4O2
- Peso molecular:371.15
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Transfluthrin (0.015-5 mg per plate; 60 min/20 min pre-incubation, 48-72 h plate incubation) is non-genotoxic in bacterial reverse mutation assays for reference transfluthrin (TFL-R), while two generic transfluthrin samples (TFL-GVI, TFL-GVIII) induce dose-dependent base-pair substitutions in Salmonella typhimurium TA100 without metabolic activation[1].
Transfluthrin is genotoxic to human nasal mucosal epithelial cells of the inferior and middle nasal conchae[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:White outbred male (220-250 g)[3]
-
Dosage:10x normal usage rate
-
Administration:Inhalation; repeated; 2 weeks
-
Result:Detected no changes in nervous system, respiratory system, or liver function parameters.
Classified products as hazard class 4.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 118712-89-3
-
Peso molecular 371.15
-
Fòrmula C15H12Cl2F4O2
-
SMILES
O=C(OCC1=C(C(F)=CC(F)=C1F)F)[C@H]2C(C)([C@@H]2/C=C(Cl)\Cl)C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz