GNPDA1 - glucosamine-6-phosphate deaminase 1 Gene

Also Known as GPI; HLN; GNP1; GNPI; GNPDA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10007

About GNPDA1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,000,671-142,013,027 (from NCBI)

This gene has 13 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 29.0), urinary bladder (RPKM 18.6) and 24 other tissues.

Summary

Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

GNPDA1 Products (1)

mRNA Protein Name
NM_005471.5 NP_005462.1 glucosamine-6-phosphate isomerase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glucosamine-6-phosphate deaminase activity IDA
IDA: Inferred from direct assay
21807125 GOA
enables glucosamine-6-phosphate deaminase activity IMP
IMP: Inferred from mutant phenotype
9438414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in UDP-N-acetylglucosamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
26887390 GOA
involved in generation of precursor metabolites and energy IMP
IMP: Inferred from mutant phenotype
9438414 GOA
involved in glucosamine catabolic process IMP
IMP: Inferred from mutant phenotype
9438414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNPDA1 Protein Structure

Glucosamine_iso

Glucosamine_iso: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (17 - 216)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

glucosamine-6-phosphate isomerase 1

  • GNPDA 1

GNPDA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNPDA1 P46926 MAGEA11 Homo sapiens P43364-2
Y2H Prey Pooling
25416956
Intra
GNPDA1 P46926 PRTFDC1 Homo sapiens Q9NRG1
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05571 GNPDA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GNPDA1 VGNC VGNC:73101
Rattus norvegicus GNPDA1 RGD RGD:1585624
Canis familiaris GNPDA1 VGNC VGNC:41331
Bos taurus GNPDA1 VGNC VGNC:29476
Felis catus GNPDA1 VGNC VGNC:62630
Mus musculus GNPDA1 MGD MGI:1347054
Others GNPDA1 NCBI