Atg14 - autophagy related 14 Gene

Also Known as Atg14L; 4832427M01; D14Ertd114e; D14Ertd436e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100504663

Summary

Predicted to enable GTPase binding activity. Involved in autophagy; cellular response to glucose starvation; and regulation of protein phosphorylation. Acts upstream of or within regulation of triglyceride metabolic process. Located in axoneme; mitochondria-associated endoplasmic reticulum membrane; and phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human ATG14 (Autophagy related 14). [provided by Alliance of Genome Resources, Apr 2022]

Atg14 Products (1)

mRNA Protein Name
NM_172599.4 NP_766187.1 beclin 1-associated autophagy-related key regulator

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22797916 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagy IMP
IMP: Inferred from mutant phenotype
19270693 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
23332761 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
26764600 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
26764600 MGI
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
23332761 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
23332761 MGI
acts upstream of or within regulation of triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
22992773 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
24089209 MGI
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
23455425 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
22493499 MGI
part of phosphatidylinositol 3-kinase complex, class III IDA
IDA: Inferred from direct assay
23332761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beclin 1-associated autophagy-related key regulator

  • Atg14-like protein

  • VATG14 autophagy related 14 homolog

  • autophagy-related protein 14-like protein

  • barkor

Atg14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atg14 Q8CDJ3 Nrbf2 Mus musculus Q8VCQ3
Anti Bait CoIP
24849286
Intra
Atg14 Q8CDJ3 Nrbf2 Mus musculus Q8VCQ3
Pull Down
24849286
Intra
Atg14 Q8CDJ3 Nrbf2 Mus musculus Q8VCQ3
GMS
24849286
Intra
Atg14 Q8CDJ3 Nrbf2 Mus musculus Q8VCQ3
Confocal
24849286
Intra
Atg14 Q8CDJ3 Nrbf2 Mus musculus Q8VCQ3
Anti Tag CoIP
24849286
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145752 HaloPROTAC-E Inhibitor 98.76% Unkown
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor 99.88% Unkown
HY-RS01142 ATG14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18164 Atg14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24638 Atg14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg14 NCBI NCBI:22863