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SGK2 - serum/glucocorticoid regulated kinase 2 Gene

Also Known as H-SGK2; dJ138B7.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10110

About SGK2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,559,027-43,585,627 (from NCBI)

This gene has 14 transcripts (splice variants), 199 orthologues and 13 paralogues. Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues.

Summary

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

SGK2 Products (3)

mRNA	Protein	Name
NM_001199264.2	NP_001186193.1	serine/threonine-protein kinase Sgk2
NM_016276.5	NP_057360.3	serine/threonine-protein kinase Sgk2
NM_170693.3	NP_733794.1	serine/threonine-protein kinase Sgk2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	12397388	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGK2 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Sgk2	SGK2, serine/threonine kinase 2

SGK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SGK2	Q9HBY8	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	SGK2	Q9HBY8	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	SGK2	Q9HBY8	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-167832	PT109	Inhibitor	99.20%	Unkown
HY-170933	SGK1-IN-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SGK2	VGNC	VGNC:65079
Rattus norvegicus	SGK2	RGD	RGD:620232
Macaca mulatta	SGK2	VGNC	VGNC:77228
Mus musculus	SGK2	MGD	MGI:1351318
Bos taurus	SGK2	VGNC	VGNC:34542
Others	SGK2	NCBI