2. Gene
  3. CELA3A - chymotrypsin like elastase 3A Gene

CELA3A - chymotrypsin like elastase 3A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ELA3; ELA3A

Gene ID: 10136 | Gene type: protein coding

About CELA3A

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,001,657-22,012,542 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 6 paralogues. Restricted expression toward pancreas (RPKM 29060.2).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, Elastase 3A has little elastolytic activity. Like most of the human elastases, Elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as protease E and as Elastase 1. [provided by RefSeq, Jul 2008]

CELA3A Products(1)

mRNA Protein Name
NM_005747.5 NP_005738.4 chymotrypsin-like elastase family member 3A preproprotein

CELA3A Protein Structure

Trypsin

Trypsin: Trypsin (30 - 263)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

chymotrypsin-like elastase family member 3A

chymotrypsin like elastase family member 3A

Recombinant CELA3A Proteins

Cat. No. Product Name Accession Purity
HY-P70133 CELA3A Protein, Human (HEK293, His) P09093 (S16-H270) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02457 CELA3A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Others CELA3A NCBI