CELA3A - chymotrypsin like elastase 3A Gene

Also Known as ELA3; ELA3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10136

About CELA3A

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,001,657-22,012,542 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 6 paralogues. Restricted expression toward pancreas (RPKM 29060.2).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike Other elastases, Elastase 3A has little elastolytic activity. Like most of the human elastases, Elastase 3A is secreted from the pancreas as a zymogen and, like Other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as protease E and as Elastase 1. [provided by RefSeq, Jul 2008]

CELA3A Products (1)

mRNA Protein Name
NM_005747.5 NP_005738.4 chymotrypsin-like elastase family member 3A preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELA3A Protein Structure

Trypsin

Trypsin: Trypsin (30 - 263)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

chymotrypsin-like elastase family member 3A

  • chymotrypsin like elastase family member 3A

CELA3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CELA3A P09093 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
CELA3A P09093 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
CELA3A P09093 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CELA3A Proteins

Cat. No. Product Name Accession Purity
HY-P70133 CELA3A Protein, Human (HEK293, His) P09093 (S16-H270) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02457 CELA3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20538 Cela3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others CELA3A NCBI