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PLXNC1 - plexin C1 Gene

Also Known as CD232; VESPR; PLXN-C1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10154

About PLXNC1

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:94,148,577-94,307,675 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 8 paralogues. Broad expression in appendix (RPKM 8.1), testis (RPKM 6.6) and 23 other tissues.

Summary

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

PLXNC1 Products (1)

mRNA	Protein	Name
NM_005761.3	NP_005752.1	plexin-C1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20727575	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNC1 Protein Structure

PSI

TIG

Plexin_cytopl

0
300
600
900
1200
1568 a.a.

Protein Preferred Names	Protein Names
plexin-C1	plexin (semaphorin receptor)

PLXNC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLXNC1	O60486	SEMA7A	Homo sapiens	O75326	ITC	20727575
Cross	PLXNC1	O60486	EVM139	Ectromelia virus	Q8JL80	ITC	20727575

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10755	PLXNC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLXNC1	VGNC	VGNC:44725
Bos taurus	PLXNC1	VGNC	VGNC:33064
Macaca mulatta	PLXNC1	VGNC	VGNC:76190
Rattus norvegicus	PLXNC1	RGD	RGD:1307420
Mus musculus	PLXNC1	MGD	MGI:1890127
Others	PLXNC1	NCBI