DHRS9 - dehydrogenase/reductase 9 Gene

Also Known as RDHL; RDH15; RDH-E2; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10170

About DHRS9

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,067,077-169,096,167 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 25 paralogues. Biased expression in colon (RPKM 23.4), esophagus (RPKM 9.8) and 12 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

DHRS9 Products (5)

mRNA Protein Name
NM_001142270.2 NP_001135742.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001142271.2 NP_001135743.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001289763.2 NP_001276692.1 dehydrogenase/reductase SDR family member 9 isoform 2
NM_001376924.1 NP_001363853.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_199204.2 NP_954674.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
11304534 GOA
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
11304534 GOA
enables androstan-3-alpha,17-beta-diol dehydrogenase activity IDA
IDA: Inferred from direct assay
11294878 GOA
enables androsterone dehydrogenase activity IDA
IDA: Inferred from direct assay
11294878 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables testosterone dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
11294878 GOA
Biological Process GO Annotation Evidence References Source
involved in 9-cis-retinoic acid biosynthetic process IDA
IDA: Inferred from direct assay
11304534 GOA
involved in androgen metabolic process IDA
IDA: Inferred from direct assay
11294878 GOA
involved in progesterone metabolic process IDA
IDA: Inferred from direct assay
11294878 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11294878 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS9 Protein Structure

adh_short

adh_short: short chain dehydrogenase (31 - 193)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
Protein Preferred Names Protein Names

dehydrogenase/reductase SDR family member 9

  • 3-alpha hydroxysteroid dehydrogenase

Recombinant DHRS9 Proteins

Cat. No. Product Name Accession Purity
HY-P76871 DHRS9 Protein, Human (His) Q9BPW9 (R18-V319) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Smith-Lemli-Opitz Syndrome

  • SLOS

  • Rsh Syndrome

  • 7-Dehydrocholesterol Reductase Deficiency

  • Slo Syndrome

  • Rutledge Lethal Multiple Congenital Anomaly Syndrome

  • Lethal Acrodysgenital Syndrome

  • Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

  • Smith-Opitz-Inborn Syndrome

  • Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

  • Smith Lemli Opitz Syndrome

  • Smith-Lemli-Opitz Syndrome, Type Ii
Postpartum Depression

  • Maternity Blues

  • Postnatal Depression

  • Depression, Postpartum

  • Post-Partum Depression

  • Depression Postpartum
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03745 DHRS9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20010 Dhrs9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26513 Dhrs9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DHRS9 VGNC VGNC:80180
Mus musculus DHRS9 MGD MGI:2442798
Macaca mulatta DHRS9 VGNC VGNC:71636
Bos taurus DHRS9 VGNC VGNC:28046
Canis familiaris DHRS9 VGNC VGNC:39937
Rattus norvegicus DHRS9 RGD RGD:620655
Others DHRS9 NCBI