DHRS9 - dehydrogenase/reductase 9 Gene

Homo sapiens

Also known as RDHL; RDH15; RDH-E2; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD

Gene ID: 10170 | Gene type: protein coding

About DHRS9

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,067,077-169,096,167 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 25 paralogues. Biased expression in colon (RPKM 23.4), esophagus (RPKM 9.8) and 12 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

DHRS9 Products(5)

mRNA	Protein	Name
NM_001142270.2	NP_001135742.1	dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001142271.2	NP_001135743.1	dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001289763.2	NP_001276692.1	dehydrogenase/reductase SDR family member 9 isoform 2
NM_001376924.1	NP_001363853.1	dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_199204.2	NP_954674.1	dehydrogenase/reductase SDR family member 9 isoform 1 precursor

DHRS9 Protein Structure

adh_short

0
100
200
300
319 a.a.

Protein Preferred Names

Protein Names

dehydrogenase/reductase SDR family member 9

3-alpha hydroxysteroid dehydrogenase

Recombinant DHRS9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76871	DHRS9 Protein, Human (His)	Q9BPW9 (R18-V319)	≥95%

Related Diseases

Diseases

Alias

Smith-Lemli-Opitz Syndrome

SLOS	Rsh Syndrome
7-Dehydrocholesterol Reductase Deficiency	Slo Syndrome
Rutledge Lethal Multiple Congenital Anomaly Syndrome	Lethal Acrodysgenital Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung	Smith-Opitz-Inborn Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung	Smith Lemli Opitz Syndrome
Smith-Lemli-Opitz Syndrome, Type Ii

Postpartum Depression

Maternity Blues	Postnatal Depression
Depression, Postpartum	Post-Partum Depression
Depression Postpartum

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03745	DHRS9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DHRS9	VGNC	VGNC:80180
Mus musculus	DHRS9	MGD	MGI:2442798
Macaca mulatta	DHRS9	VGNC	VGNC:71636
Bos taurus	DHRS9	VGNC	VGNC:28046
Canis familiaris	DHRS9	VGNC	VGNC:39937
Rattus norvegicus	DHRS9	RGD	RGD:620655
Others	DHRS9	NCBI

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