CD96 - CD96 molecule Gene

Also Known as TACTILE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10225

About CD96

Cytogenetic location: 3q13.13-q13.2 Genomic coordinates (GRCh38): 3:111,542,197-111,665,996 (from NCBI)

This gene has 7 transcripts (splice variants), 106 orthologues and is associated with 3 phenotypes. Broad expression in lymph node (RPKM 4.8), appendix (RPKM 2.7) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

CD96 Products (4)

mRNA Protein Name
NM_001318889.2 NP_001305818.1 T-cell surface protein tactile isoform 3
NM_001410800.1 NP_001397729.1 T-cell surface protein tactile isoform 4
NM_005816.5 NP_005807.1 T-cell surface protein tactile isoform 2 precursor
NM_198196.3 NP_937839.1 T-cell surface protein tactile isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
17847009 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17847009 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD96 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (25 - 135)

Ig_3

Ig_3: Immunoglobulin domain (271 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

T-cell surface protein tactile

  • T cell activation, increased late expression

Recombinant CD96 Proteins

Cat. No. Product Name Accession Purity
HY-P72698 CD96 Protein, Human (HEK293, His) P40200-2 (V22-M503) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75371 CD96 Protein, Human (Biotinylated, HEK293, His) P40200-2 (V22-M503) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P78420 CD96 Protein, Human (HEK293, mFc) P40200-2 (V22-M503) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78660 CD96 Protein, Human (C110S, HEK293, His) P40200-2 (V22-M503, C110S) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700855 CD96 Protein, Human (Biotinylated, HEK293, His-Avi) P40200-2 (V22-M503) ≥ 95%, as determined by reducing SDS-PAGE.

CD96 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84296 CD96 Antibody (YA3993) WB, FC, ELISA Human, Mouse
HY-P84296A CD96 Antibody (YA3993)(PBS only) WB, FC, ELISA Human, Mouse
HY-P85013 CD96 Antibody (YA4705) ELISA Human

Related Diseases

Diseases Alias
C Syndrome

  • Opitz Trigonocephaly Syndrome

  • Trigonocephaly

  • Trigonocephaly Syndrome

  • Trigonocephaly C Syndrome

  • Opitz C Trigonocephaly

  • Opitz Trigonocephaly C Syndrome

  • Otcs

  • CSYN
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0640 Epinastine 98.0% Unkown
HY-B0640A Epinastine hydrochloride 99.86% Unkown
HY-B0640AR Epinastine hydrochloride (Standard) / Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990053 Nelistotug Inhibitor 96.59% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02279 CD96 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18232 Cd96 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24711 Cd96 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990259 Anti-Mouse CD96 Antibody (3.3) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CD96 VGNC VGNC:102640
Bos taurus CD96 VGNC VGNC:27054
Canis familiaris CD96 VGNC VGNC:38982
Rattus norvegicus CD96 RGD RGD:1565249
Macaca mulatta CD96 VGNC VGNC:70773
Mus musculus CD96 MGD MGI:1934368
Others CD96 NCBI