EIF1B - eukaryotic translation initiation factor 1B Gene

Also Known as GC20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10289

About EIF1B

This gene has 4 transcripts (splice variants), 158 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 113.1), bone marrow (RPKM 72.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF1B Products (1)

mRNA Protein Name
NM_005875.3 NP_005866.1 eukaryotic translation initiation factor 1b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1B Protein Structure

SUI1

SUI1: Translation initiation factor SUI1 (26 - 105)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 1b

  • protein translation factor SUI1 homolog GC20

EIF1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF1B O60739 FUS Homo sapiens P35637
Y2H Pooling
32814053
Intra
EIF1B O60739 FUS Homo sapiens P35637
Anti Bait CoIP
17353931
Intra
EIF1B O60739 FUS Homo sapiens P35637
Validated Y2H
32814053
Intra
EIF1B O60739 FUS Homo sapiens P35637
Y2H Array
32814053
Intra
EIF1B O60739 UCHL1 Homo sapiens P09936
Anti Bait CoIP
17353931
Intra
EIF1B O60739 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
EIF1B O60739 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
EIF1B O60739 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
EIF1B O60739 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
Intra
EIF1B O60739 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
EIF1B O60739 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1B Proteins

Cat. No. Product Name Accession Purity
HY-P70207 EIF1B Protein, Human (His) O60739 (M1-F113) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Mixed Cell Uveal Melanoma

  • Intraocular Mixed Cell Type Melanoma

  • Mixed Cell Type Uveal Melanoma
Posterior Uveal Melanoma

  • Medium/Large Size Posterior Uveal Melanoma

  • Small Size Posterior Uveal Melanoma

  • Ciliary Body And Choroid Melanoma, Medium/Large Size

  • Ciliary Body And Choroid Melanoma, Small Size
Choroid Cancer

  • Choroid Neoplasm

  • Choroidal Tumor

  • Malignant Tumor Of Choroid

  • Malignant Tumor Of The Choroid

  • Neoplasm Of Choroid

  • Choroid Neoplasms

  • Primary Malignant Neoplasm Of Choroid
Transposition Of The Great Arteries, Dextro-Looped

  • Transposition Of The Great Arteries

  • DTGA1

  • Dextro-Looped Transposition Of The Great Arteries

  • DTGA

  • Congenitally Uncorrected Transposition Of The Great Arteries

  • Congenitally Uncorrected Transposition Of The Great Vessels

  • D-Tga

  • Isolated Ventriculoarterial Discordance

  • Ventriculoarterial Discordance With Atrioventricular Concordance

  • Dextro-Transposition Of The Great Arteries

  • Transposition Of The Great Vessels

  • Great Vessels Transposition

  • Transposition Of The Great Arteries, Dextro-Looped 1

  • Arteries, Great, Transposition, Dextro-Looped

  • Ventriculoarterial Discordance, Isolated

  • D-Transposition Of The Great Arteries

  • Complete Transposition

  • Tga

  • Tgv

  • Transposition Of Great Vessels

  • Transposition Of The Great Arteries Dextro-Looped 1

  • Dextro-Looped Transposition Of The Great Arteries 1

  • Discordant Ventriculoarterial Connection

  • Complete Transposition Of Great Vessels

  • Great Vessels Complete Transposition

  • Total Great Vessel Transposition

  • Transposition Of Great Arteries

  • Complete Tga - [Transposition Of The Great Arteries]

  • Tga - [Transposition Of Great Arteries]

  • Tgv - [Transposition Of Great Vessels]

  • Transposition Of Great Vessels Nos

  • Transposed Vessels Nos
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04240 EIF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18660 Eif1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25146 Eif1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF1B VGNC VGNC:28378
Felis catus EIF1B VGNC VGNC:61768
Mus musculus EIF1B MGD MGI:1916219
Rattus norvegicus EIF1B RGD RGD:1309241
Macaca mulatta EIF1B VGNC VGNC:110369
Others EIF1B NCBI