NMUR1 - neuromedin U receptor 1 Gene

Also Known as FM3; FM-3; GPC-R; GPR66; NMU1R; (FM-3)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10316

About NMUR1

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,518,455-231,530,445 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues and 15 paralogues. Broad expression in fat (RPKM 2.5), lung (RPKM 1.6) and 20 other tissues.

Summary

Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of Phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

NMUR1 Products (1)

mRNA	Protein	Name
NM_006056.5	NP_006047.3	neuromedin-U receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables neuromedin U binding	IDA IDA: Inferred from direct assay	10894543	GOA
enables neuromedin U receptor activity	IDA IDA: Inferred from direct assay	10894543	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	10894543	GOA
involved in chloride transport	IDA IDA: Inferred from direct assay	10899166	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10899166	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	10899166	GOA
involved in smooth muscle contraction	IEP IEP: Inferred from expression pattern	10899166	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	10899166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMUR1 Protein Structure

7tm_1

0
100
200
300
400
426 a.a.

Protein Preferred Names	Protein Names
neuromedin-U receptor 1	G-protein coupled receptor 66

Related Diseases

Diseases	Alias
Spherocytosis, Type 3	Hereditary Spherocytosis Type 3 SPH3 Hs3 Spherocytosis, Hereditary, 3 Hereditary Spherocytosis 3 Spherocytosis 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10473A	CPN-351 TFA	Antagonist	99.60%	Unkown
HY-P10473	CPN-351	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NMUR1	VGNC	VGNC:99388
Felis catus	NMUR1	VGNC	VGNC:67438
Mus musculus	NMUR1	MGD	MGI:1341898
Rattus norvegicus	NMUR1	RGD	RGD:619867
Bos taurus	NMUR1	VGNC	VGNC:32140
Canis familiaris	NMUR1	VGNC	VGNC:59087