Kdm3a - lysine (K)-specific demethylase 3A Gene

Also Known as TGSA; Tsga; Jmjd1; KDM2A; JHDM2a; Jmjd1a; 1700105C21Rik; C230043E16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104263

Summary

Enables chromatin binding activity and transcription coregulator activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; histone modification; and spermatid nucleus elongation. Located in cytoplasm and nucleus. Is expressed in pituitary gland. Used to study obesity. Human ortholog(s) of this gene implicated in cervical Cancer and colon Cancer. Orthologous to human KDM3A (lysine demethylase 3A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm3a Products (4)

mRNA Protein Name
NM_001038695.3 NP_001033784.2 lysine-specific demethylase 3A isoform a
NM_001362200.1 NP_001349129.1 lysine-specific demethylase 3A isoform a
NM_001362201.1 NP_001349130.1 lysine-specific demethylase 3A isoform b
NM_173001.3 NP_766589.1 lysine-specific demethylase 3A isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
17943087 MGI
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
17991879 MGI
enables histone H3K9 demethylase activity IMP
IMP: Inferred from mutant phenotype
17938240 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17991879 MGI
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
17991879 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
19194461 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17991879 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17938240 MGI
acts upstream of or within regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17938240 MGI
acts upstream of or within regulation of stem cell population maintenance IGI
IGI: Inferred from genetic interaction
17938240 MGI
acts upstream of or within spermatid nucleus elongation IMP
IMP: Inferred from mutant phenotype
17943087 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
17943087 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17943087 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
17943087 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17599069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 3A

  • [histone H3]-dimethyl-L-lysine(9) demethylase 3A

  • jmjC domain-containing histone demethylation protein 2A

  • jumonji domain-containing protein 1A

  • testis specific gene A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-168593 PROTAC KDM3 degrader-1 99.07% Unkown
HY-RS07211 KDM3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS17111 Kdm3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23556 Kdm3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm3a NCBI NCBI:55818